Research

Screening for Circulating Tumour Cells Allows Early Detection of Cancer and Monitoring of Treatment Effectiveness: An Observational Study "Circulating-Tumour-Cells (CTC) provide a blood biomarker for early carcinogenesis, cancer progression and treatment effectiveness."

Clinical significance of circulating tumor cell (CTC)-specific microRNA (miRNA) in breast cancer "As a noninvasive method, circulating tumor cell (CTC) provides ideal liquid biopsy specimens for early cancer screening and diagnosis." "CTCs were described as cells shed by a primary tumor mass into circulation distant from the original sites. This finding implied that cancer cells can travel to distant organs through the circulation and thus CTCs have been considered as an critical factor in metastasis development ever since."

"Circulating tumour cells for early detection of clinically relevant cancer "CTCs have been detected in patients with early-stage cancers and, owing to their association with metastasis, might indicate the presence of aggressive disease, thus providing a possible means to expedite diagnosis and treatment initiation for such patients while avoiding overdiagnosis and overtreatment of those with slow-growing, indolent tumors." "Globally, cancer is the second most common cause of death1, driven by mortality rates that increase with disease stage at diagnosis. Detecting cancer at an advanced stage severely limits treatment options and typically results in a poor prognosis. Indeed, the options available for patients with metastatic solid tumors are very rarely curative."

Circulating Tumor Cell Detection Technologies and Clinical Utility: Challenges and Opportunities "The rate of tumor shedding has been estimated to be around 3.2 million cells per gram of tumor per day."

"Circulating tumor cells: biology and clinical significance "Metastasis is the most lethal feature of cancer." "CTCs are defined as tumor cells that have been sloughed from the primary tumor and are swept away by the circulatory or lymphatic systems."

"Identifying cancer origin using circulating tumor cells "This CTC identification concept can also apply to any types of CTC enumerating systems, which allows the possibility of early cancer detection in a most efficient way."

"Sensitive detection of CTCs from clinical samples can serve as an effective tool in cancer diagnosis and prognosis through liquid biopsy."

"The estimated share of total annual deaths from each cause."

Cancer Statistics "According to the National Cancer Institute, cancer prevalence is expected to rise to 39.5%, where nearly four out of ten people will be diagnosed with cancer in their lifetime."

"Diagnosing cancer in late stages, and the inability to provide treatment, condemns many people to unnecessary suffering and early death."

Circulating Tumor Cells: Fluid Surrogates of Solid Tumors "Evaluation of circulating tumor cells (CTCs) has demonstrated clinical validity as a prognostic tool." "CTCs are surrogates of a tumor in the bloodstream."